Description
Clinical pharmacology-The 0.1% concentraion of tacrolimus ointment was approved for the treatment of adults, while the lower 0.3% concentration of “Tacrol” was approved for the treatment of both children (ages two and above) and adults for short term and intermittent long term therpy.
The exact mechanism of action of Tacroliums is not known, however, “Tacrol” is a topical immunomodulator (TIM) That acts at the
site of the immune imbalance to help in stop, the autoimmune reaction.
Pharmacokinrtics- Tacroliumus is metabolized in the liver but with topical use very little quantity is absorbed. There was no eviidence of systemic accumulation of Tacrolimus in Patients (adults and children) Treated for prolonged (up to one year) with “Tacrol” Ointment.
Tacroliums ——0.03%w/w
Ointment base —–q.s.
(Squalene, Aloe Vera, Vit. E, White Soft Paraffin & Jojoba oil)
Tacrol ointment contains Immunosuppressant agent Tacrolimus.It is a macrolide lactone product by Streptomyces tsukubaensis. It is for only.
A common side effevt of Tacrolimus ointment, if used over a wide area, is to cause a burnig or itching sensation on the first one or two applications. Less common side effects include flu-like symptoms, headache, cough and burning eyes.